乳腺癌在全世界女性中是最常见的癌症类型，而姜黄素则对其具有有效的抑制作用。
在最新一期的《Food Science and Human Wellness》中，来自台北医学大学医学研究所的Hui-Tien Liu和Yuan-Soon Ho 提到：大量研究表明，姜黄素是一种通过抑制癌细胞的增殖、转移以及诱导细胞周期停滞和细胞凋亡而发挥抗癌作用的天然化合物。它对能表达激素受体ER的乳腺癌细胞系具有较低的最大抑制浓度，并使细胞系对抗癌药物敏感。此外，它可以独立于激素受体的表达而诱导细胞系中的细胞凋亡。此外，姜黄素还可以抑制乳腺癌干细胞（BCSC）的增殖，这是影响癌症复发的重要因素。对BCSC增殖的抑制可以进一步抑制转移和再附着，因而最终限制肿瘤的形成。异种移植研究同样表明，姜黄素对癌细胞和癌症干细胞发挥肿瘤抑制作用。
因此，姜黄素是一种潜在的抗癌化合物，与其他抗癌药物同时应用也许会发挥更有效的作用。
文章摘要
ABSTRACT
Anticancer effect of curcumin on breast cancer and stem cells
Hui-Tien Liu a,?, Yuan-Soon Ho a,b
aGraduate Institute of Medical Sciences, College of Mediine, Taipei Medical University, Taipei, Taiwan, China
bGraduate Institute of Medical Sciences, College of Medical Science and Technology, Taipei Medical University, Taipei,Taiwan, China
Abstract
Numerous studies have shown that curcumin, a natural compound, exerts anticancer effects by inhibiting cancer cell proliferation and metastasis and by inducing cell cycle arrest and apoptosis. In particular, curcumin exhibits potent inhibitory effects on breast cancer, the most prevalent type of cancer among women worldwide. It has low maximal inhibitory concentration for breast cancer cell lines that express the hormone receptor ER and sensitizes cell lines to anticancer drugs. Moreover, it can induce apoptosis in cell lines independently of hormone receptor expression. In addition, curcumin inhibits the proliferation of breast cancer stem cells (BCSC), an important factor that influences cancer recurrence. The inhibition of BCSC proliferation suppresses metastasis and reattachment, ultimately limiting tumor formation. A xenograft study similarly showed that curcumin exerts tumor-suppression effects on cancercells and cancer stem cells. Therefore, curcumin is a potential anticancer compound, and its concurrent application with other anticancer drugs appears promising.
