在该研究中，南昌大学生命科学与食品工程学院食品科学与技术国家重点实验室的Tinglan Yuan、Xuemei Zhu*和Hua Xiong*等人通过对四种配方奶粉（IF1、2、3、4）进行比较，其中包括富含OPO脂质的婴儿配方奶粉（IF1和IF3）和含有常见混合植物油的婴儿配方奶粉（IF2和IF4），研究了人乳的体外脂肪消化特性。
结果显示，人乳的最终脂质水解程度（98.9±2.70％）高于IF1、IF3（分别为（90.4±3.39）％、（91.1±1.67）％）（p<0.05）以及IF2、IF4（分别为（81.9±1.64）％、（79.9±1.05）％）（p<0.01）。在人乳胃消化结束时观察到天然脂肪球和蛋白质聚集，聚集体变小然后在小肠消化中溶解60～120分钟，而在婴儿配方奶粉中观察到大量聚集体，这可能会减慢脂质的消化。人乳和婴儿配方奶粉在脂质消化方面的吸收差异需要进一步研究，以阐明其与婴儿生长发育的营养相关性。
Effects of Chemical Composition and Microstructure in Human Milk and Infant Formulas on Lipid Digestion
Tinglan Yuan1, Xuemei Zhu1,2,*, Guangqing Mu2, Fang Qian2, Hua Xiong1,*
1State Key Lab of Food Science and Technology, Collegeof Life Science and Food Engineering, Nanchang University, Nanchang 330047,Jiangxi, China
2College of Food Science, Dalian PolytechnicUniversity, Dalian 116034, Liaoning, China
Abstract
Infant formula (IF) is an important substitute for infants when human milk (HM) is unavailable; however, it was often observed with “insufficient fat” and showed different metabolic phenotypes, which may affect the growth and brain development of the infant. Considering that the milk fat digestion rate may affect the fat absorption and metabolism and further influence the metabolic phenotype, it is valuable to study the fat digestive behaviors of IF and HM. In the current study, we investigated the in vitro fat digestive properties of HM in comparison to four formulas (IF1, 2, 3, 4) including IFs enriched in OPO lipids (IF1 and IF3) and IFs with common mixed plant oils (IF2 and IF4). Results showed that the extent of eventual lipid hydrolysis of HM (98.9 ± 2.70%) was higher than those of IF1 and IF3 (90.4 ± 3.39 and 91.1 ± 1.67%, respectively) (p < 0.05) and IF2 and IF4 (81.9 ± 1.64 and 79.9 ± 1.05% respectively) (p < 0.01). Native fat globules and protein aggregation were observed at the end of HM gastric digestion, and the aggregates became smaller and then resolved from 60 to 120 min in intestinal digestion, while a large number of aggregates were observed in IF, which may slow the lipid digestion. The absorption differences between HM and IFs in lipid digestion need further study to elucidate the nutritional relevance to infant development and growth.
