2: After the reaction mixture was cooled to 0 ℃, the reaction mixture was quenched by addition of x mL of H 2 O, followed by x mL of 15% aqueous NaOH. After being stirred at
room temperature for x hour, the solid was removed by filtration (or the mixture was filtered through Celite pad to remove by-product). The filtrate was concentrated to dryness to give
crude product. [LiAlH 4 反应的经典后处理]
3: The mixture was diluted with water (x mL), neutralized with solid K 2 CO 3 until no CO 2 was evolved. [适用于酸性反应液的后处理]
4: The suspension was filtered through a pad of Celite or silica gel and the pad or filter cake was washed with EtOH (x mL×x). The combined filtrates were concentrated to dryness to give product (x g, x%) as. [适用氢化反应的后处理, 或者难于过滤的反应液的后处理, 但要注意的是这里需要的是滤液而不是固体才能添加助滤剂]
5: The reaction mixture was poured into x mL of ice-water carefully and the organic layer or phase was separated. [产物在有机相里]
6: The reaction mixture was poured into x mL of ice-water carefully and the aqueous phase was washed with Et 2 O (x mL×x) [产品在水相] and acidified with 1N HCl to pH=3. The
resulting precipitate was collected by filtration or the resulting solution was extracted with EA (x mL×x).
7: The reaction mixture was filtered and the filter cake was washed with x mL of solvent, dried in vacuum to give or afford product. [这里需要的是固体而不是滤液]
8: The reaction mixture was quenched with x mL of saturated aqueous NH 4 Cl. The resulting solution was extracted with EA (x mL×x). [适用于丁基锂等活泼金属有机物的后处理]
10: The residue was triturated with ether and filtered to afford a white solid. (磨碎)
11: The crude product was purified by prep. HPLC to give A as a colorless thick oil which was solidified on standing. (静止固化)
12: After prep. HPLC purification, the eluent was concentrated or evaporated to remove organic solvents. The residual aqueous solution was lyophilized to give a white solid. (冷冻干燥)
13: After concentration, the crude product was used directly for the next step without purification.
